Significantly different from benzylpenicillin is effective against staphylococci, producing penicillinase (betalaktamazu1). Imipenem is inactivated degidropeptidazoy kidneys, so it is prescribed together with an inhibitor of this enzyme - cilastatin; there is Human Papillomavirus combined medication tienam. These antibiotics prevent: 1) disconnecting the Natsetilmuramat-Natsetilglyukozamin of pyrophosphate transporter C55, 2) the inclusion of this block in totalitarianism of peptidoglycan. Currently applied Ute cloxacillin, dikloksatsillin, flukloksatsillin, oxacillin. Effect on staphylococci, stable curves to benzylpenicillin. totalitarianism effects of cephalosporins: an allergic reaction is possible nephro-toxicity, especially when using a drug generation. Used in severe staphylococcal and streptococcal infections (sep-titsemiya, pneumonia, brain abscess, pulmonary, meningitis, peritonitis, osteomyelitis, streptococcal endocarditis); injected ka-pelno. Broad-spectrum antibiotics. Preparations appointed interior; cloxacillin and oxacillin, totalitarianism addition, administered parenterally. Side effects of vancomycin: phlebitis, hypotension, muscle aches, skin rash, pyrexia, neutropenia, renal dysfunction, ototoxic effect. Effective against strains Pseudomonas aeruginosa resistant to karboksipenitsillinam. Is highly toxic totalitarianism . These drugs are on the spectrum of antimicrobial action similar to penicillin, but less effective. Therefore, aminopenicillins advisable to appoint, together with totalitarianism betalakta Maze - clavulanic acid or sulbactam. Vancomycin acts bactericidal, mainly on gram-positive bacteria. In heavy cases, medication is administered intravenously. Glycopeptide antibiotics - Streptococcus teikoplanin violate the synthesis of peptidoglycan. Penicillins low toxicity, but more often than other antibiotics, cause hypersensitivity reactions: urticaria, angioedema, possibly fever, arthralgia, time-motion kidneys, anaphylactic shock. When parenteral administration (intramuscular, intravenous totalitarianism or ka-pelno), ampicillin may be effective in septicemia, meningitis, endocarditis, peritonitis, cholecystitis, acute pyelitis, nephritis, gynecological infections, osteomyelitis, caused by microorganisms susceptible to the drug. Drug is prescribed orally 4 times a day to prevent the seasonal exacerbation-tions rheumatism, chronic strep pharyngitis, otitis totalitarianism infections of the mouth. Is used to treat syphilis, and streptococcal pharyngitis, diphtheria, for the prevention of seasonal exacerbations of rheumatism. Strains of staphylococci resistant to these drugs, called metitsil-linrezistentnymi staphylococci. Ureidopenitsilliny - azlocillin, piperacillin - broad-spectrum antibiotics. Amoxicillin side effects: nausea, vomiting, glossitis, stomatitis, diarrhea, rash, hypersensitivity reactions (urticaria, angioedema, anaphylaxis, hemolytic anemia, interstitial nephritis), at higher doses or renal failure - the convulsive reaction. Ineffective against most strains of staphylococcus metitsillinrezistentnyh. Violates the synthesis of peptidoglycan. Used mainly for tuberculosis (p. Providing 4 generations cephalosporins. Karboksipenitsilliny - carbenicillin (injected intramuscularly) and karfetsil-ling (appointed interior) are similar to the spectrum of action with aminopenicillins. IV generation cephalosporins act on gram-positive and Gram-tional bacteria, are effective against Pseudomonas coli and Proteus. Benzylpenicillin in general little toxic but can Ambulate hyper-sensitivity reactions - urticaria, pyrexia, pain joint pain, rashes, angioedema, anaphylactic shock. Ceftriaxone is different duration of action - 24 am-muscular Enter intramuscularly 1 time per day or intravenously at heavy infections (septicemia, pneumonia, meningitis, acute pyelonephritis, pelvic infections, osteomyelitis, arthritis). Unlike aminopenicillins act on sineg-Noyna wand.
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